John Wayne Casserole

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John Wayne Casserole – A Hearty, Cheesy Tex-Mex Classic

When it comes to comfort food, few dishes hit the spot like a warm, cheesy casserole. And this John Wayne Casserole is a true standout. Named after the legendary cowboy himself, this dish is as bold and satisfying as the man it honors. With layers of seasoned ground beef, sautéed veggies, creamy ranch sour cream, and gooey melted cheese all baked over a fluffy biscuit crust, it’s the kind of meal that brings everyone to the table.

Whether you’re feeding a hungry family, hosting a casual dinner, or prepping for a potluck, this casserole is guaranteed to please. It’s easy to make, packed with flavor, and endlessly customizable.

Why You’ll Love This Casserole

  • Hearty and filling – Loaded with protein, cheese, and veggies.
  • Bold Tex-Mex flavor – Taco seasoning, Rotel, and ranch bring the heat and zest.
  • Comfort food classic – Warm, cheesy, and satisfying.
  • Perfect for gatherings – Feeds a crowd and reheats beautifully.
  • Easy to make – Simple steps and pantry-friendly ingredients

Ingredients

This recipe serves 6 generous portions.

For the Meat and Veggie Layer

  • 1 pound ground beef
    Lean or regular—just drain excess fat after browning.
  • 1 medium onion, chopped
    Adds sweetness and depth.
  • 1 medium bell pepper, chopped
    Use red, green, or yellow for color and crunch.
  • 1 (10-ounce) can diced tomatoes with green chilies (like Rotel), drained
    Adds tangy heat and moisture.
  • 1 packet taco seasoning
    Classic Tex-Mex flavor in one easy step.

For the Crust

  • 1 (8-ounce) can refrigerated biscuits
    Forms the fluffy, golden base of the casserole.

For the Creamy Ranch Layer

  • 1 cup sour cream
    Adds tang and creaminess.
  • 1 cup mayonnaise
    Rich and smooth—balances the spices.
  • 1 packet ranch dressing mix
    Infuses the topping with herby, savory flavor.

For the Topping

  • 1 cup shredded cheddar cheese
    Sharp and melty.
  • 1 cup shredded Monterey Jack cheese
    Creamy and mild—melts beautifully.
  • 1 (4-ounce) can sliced jalapeños (optional)
    For a spicy kick—adjust to taste.

Equipment You’ll Need

  • Large skillet
  • Mixing bowls
  • 9×13-inch baking dish
  • Spatula or wooden spoon
  • Measuring cups and spoons
  • Oven

Step-by-Step Instructions

Step 1: Preheat and Prep

Preheat your oven to 350°F (175°C).

Grease a 9×13-inch baking dish with nonstick spray or butter.

Step 2: Cook the Beef and Veggies

In a large skillet over medium heat, add:

  • 1 pound ground beef

Cook until browned, breaking it up with a spoon.

Add:

  • 1 chopped onion
  • 1 chopped bell pepper

Sauté for 5–7 minutes, until the vegetables are soft and fragrant.

Stir in:

  • 1 packet taco seasoning
  • 1 can diced tomatoes with green chilies (drained)

Cook for another 3–5 minutes, stirring occasionally.

Remove from heat and set aside.

Step 3: Prepare the Biscuit Crust

Open the can of refrigerated biscuits and press them into the bottom of the prepared baking dish to form an even layer.

Pre-bake the biscuit crust for 5 minutes, just until it begins to puff.

Tip: This step helps prevent a soggy bottom and ensures the biscuits cook through.

Step 4: Layer the Casserole

Spread the beef and veggie mixture evenly over the partially baked biscuit crust.

In a medium bowl, mix:

  • 1 cup sour cream
  • 1 cup mayonnaise
  • 1 packet ranch dressing mix

Stir until smooth and well combined.

Spread the ranch sour cream mixture evenly over the beef layer.

Step 5: Add the Cheese and Jalapeños

Top the casserole with:

  • 1 cup shredded cheddar cheese
  • 1 cup shredded Monterey Jack cheese

If using, scatter sliced jalapeños over the top for a spicy finish.

Step 6: Bake

Bake the casserole in the preheated oven for 25–30 minutes, or until the cheese is melted and bubbly and the biscuit base is golden and cooked through.

Tip: Let the casserole rest for 5–10 minutes before slicing to help it set.

Time & Yield

  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Total Time: 45 minutes
  • Yield: 6 servings
  • Calories: ~520 kcal per serving (approximate)

Tips for Success

  • Drain the tomatoes well to avoid excess moisture.
  • Pre-bake the biscuits to ensure a firm base.
  • Use freshly shredded cheese for better melt and flavor.
  • Customize the heat by adjusting the amount of jalapeños or using mild taco seasoning.
  • Let it rest before serving for cleaner slices and better texture.

Variations to Try

  • Spicy Southwest Style: Add black beans, corn, and a dash of hot sauce.
  • Low-Carb Version: Skip the biscuit crust and layer over sautéed cauliflower rice.
  • Chicken Ranch Casserole: Swap ground beef for shredded rotisserie chicken.
  • Vegetarian Option: Use plant-based crumbles and add extra veggies like zucchini or mushrooms.
  • Breakfast Twist: Use breakfast sausage and top with scrambled eggs before baking.

Serving Suggestions

Pair this casserole with:

  • A crisp green salad with lime vinaigrette
  • Cilantro-lime rice or Spanish rice
  • Cornbread or tortilla chips
  • A cold glass of iced tea or a light beer

Storage & Reheating

  • Refrigerate: Store leftovers in an airtight container for up to 4 days.
  • Reheat: Warm in the oven at 325°F or microwave in 30-second intervals.
  • Freeze: Wrap tightly and freeze for up to 2 months. Thaw overnight before reheating.

Final Thoughts

This John Wayne Casserole is a bold, satisfying dish that brings together the best of Tex-Mex and classic comfort food. With its layers of seasoned beef, creamy ranch topping, and gooey cheese, it’s a guaranteed hit for any occasion. Whether you’re feeding a crowd or just craving something hearty and delicious, this casserole delivers every time.

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